Nuclear Changes Following Treatment With Actinomycin D

A reevaluation of nuclear and nucleolar changes induced in vitro by actinomycin D.

Experimental studies with actinomycin D.

Actinomycin D has been tested on mouse tu mors, with varying degrees of success, as an anti-neoplastic agent. Dramatic inhibition of some ascites (mouse) tumors has been reported by Sugiura (14) and Gregory et al. (6). Reilly (11) and Sugiura (14) are in agreement that actino-mycin D has slight antineoplastic activity against S-180, and Farber (3) demonstrated antitumor activity against the mal...

Actinomycin D prevents nuclear processing of estrogen receptor.

This communication describes a novel effect of actinomycin D (AcD) in inhibiting the nuclear processing or turnover of estrogen receptors in the human breast cancer cell line. MCF-7. In the absence of AcD, estradiol treatment results in rapid (5 min) hormone binding and translocation of unfilled cytoplasmic receptors (Rc) and binding of unfilled nuclear receptors (Rn). Thereafter, filled nuclea...

Actinomycin D in Wilm's Tumour: Treatment of Lung Metastases.

This paper discusses recent world trends in the treatment of Wilms' tumour, particularly as exemplified by their impact on practice at the Royal Children's Hospital, Melbourne. Following the use of actinomycin D in the therapy of lung metastases of Wilms' tumour (see below), it became apparent that this drug was able, at times, to inhibit their growth and, more rarely, to cause their complete r...

Actinomycin D in Wilms' Tumour: Treatment of Lung Metastases* By

This paper discusses recent world trends in the treatment of Wilms' tumour, particularly as exemplified by their impact on practice at the Royal Children's Hospital, Melbourne. Following the use of actinomycin D in the therapy of lung metastases of Wilms' tumour (see below), it became apparent that this drug was able, at times, to inhibit their growth and, more rarely, to cause their complete r...